Genetic engineering of Nicotiana tabacum for reduced nornicotine content.

  title={Genetic engineering of Nicotiana tabacum for reduced nornicotine content.},
  author={Lily B Gavilano and Nicholas P. Coleman and Leigh-Emma Burnley and Melissa L Bowman and Newton E Kalengamaliro and Alec Hayes and Lowell Bush and Balazs Siminszky},
  journal={Journal of agricultural and food chemistry},
  volume={54 24},
UNLABELLED Nornicotine is an undesirable secondary alkaloid in cultivated tobacco, because it serves as a precursor to N'-nitrosonornicotine (NNN), a tobacco-specific nitrosamine with suspected carcinogenic properties. Nornicotine is produced through the oxidative N-demethylation of nicotine by a nicotine N-demethylase enzyme during the senescence and curing of tobacco leaves. While the nornicotine content of most commercial burley tobacco is low, a process termed "conversion" can bestow… CONTINUE READING


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