Genetic engineering of Escherichia coli for enhanced uptake and bioaccumulation of mercury.

@article{Bae2001GeneticEO,
  title={Genetic engineering of Escherichia coli for enhanced uptake and bioaccumulation of mercury.},
  author={Weon Bae and Rajesh K. Mehra and Ashok Mulchandani and Wilfred Chen},
  journal={Applied and environmental microbiology},
  year={2001},
  volume={67 11},
  pages={5335-8}
}
Synthetic phytochelatins (ECs) are a new class of metal-binding peptides with a repetitive metal-binding motif, (Glu-Cys)(n)Gly, which were shown to bind heavy metals more effectively than metallothioneins. However, the limited uptake across the cell membrane is often the rate-limiting factor for the intracellular bioaccumulation of heavy metals by genetically engineered organisms expressing these metal-binding peptides. In this paper, two potential solutions were investigated to overcome this… CONTINUE READING
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