Genetic engineering of Escherichia coli for production of tetrahydrobiopterin.


Tetrahydrobiopterin (BH4) is an essential cofactor for various enzymes in mammals. In vivo, it is synthesized from GTP via the three-step pathway of GTP cyclohydrolase I (GCHI), 6-pyruvoyl-tetrahydropterin synthase (PTPS) and sepiapterin reductase (SPR). BH4 is a medicine used to treat atypical hyperphenylalaninemia. It is currently synthesized by chemical… (More)


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@article{Yamamoto2003GeneticEO, title={Genetic engineering of Escherichia coli for production of tetrahydrobiopterin.}, author={Katsuhiko Yamamoto and Eri Kataoka and Nobue Miyamoto and Kazuaki Furukawa and Kazuhiro Ohsuye and Masayuki Yabuta}, journal={Metabolic engineering}, year={2003}, volume={5 4}, pages={246-54} }