Genetic engineering combined with random mutagenesis to enhance G418 production in Micromonospora echinospora


G418, produced by fermentation of Micromonospora echinospora, is an aminoglycoside antibiotic commonly used in genetic selection and maintenance of eukaryotic cells. Besides G418, M. echinospora produces many G418 analogs. As a result, the G418 product always contains impurities such as gentamicin C1, C1a, C2, C2a, gentamicin A and gentamicin X2. These… (More)
DOI: 10.1007/s10295-014-1479-3

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