Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice.

@article{Glasser1991GeneticEF,
  title={Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice.},
  author={Stephan W. Glasser and Thomas R. Korfhagen and Susan E. Wert and M. Peral de Bruno and K M McWilliams and D K Vorbroker and Jeffrey A. Whitsett},
  journal={The American journal of physiology},
  year={1991},
  volume={261 4 Pt 1},
  pages={L349-56}
}
Transgenic mice bearing chimeric genes consisting of 5'-sequences derived from the human surfactant protein C (SP-C) gene and the bacterial chloramphenicol acetyltransferase (CAT) gene were generated. Analysis of CAT activity was utilized to demonstrate tissue-specific and developmental expression of chimeric genes containing 3.7 kb of sequences from the human SP-C gene. Lung-specific expression of the 3.7 SP-C-CAT transgene was observed in eight distinct transgenic mouse lines. Expression of… CONTINUE READING
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