Genetic effects of common polymorphisms in estrogen receptor alpha gene on osteoarthritis: a meta-analysis.


OBJECTIVE The estrogen receptor alpha (ESR1) gene has been implicated in the etiology of osteoarthritis (OA). However, the results are conflicting. We assessed the association of three common ESR1 polymorphisms, rs2234693, rs9340799 and rs2228480, with OA in this meta-analysis. METHODS A comprehensive search was performed to identify related studies… (More)


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