Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach

@article{Qesseveur2016GeneticDO,
  title={Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach},
  author={Ga{\"e}l Qesseveur and Anne-C{\'e}cile Petit and Hai Thanh Nguyen and Lionel Dahan and Romain Colle and Samuel Rotenberg and Isabelle Seif and Pauline Robert and Denis J David and Jean-Philippe Guilloux and Alain M. Gardier and C{\'e}line Verstuyft and Laurent Becquemont and Emmanuelle Corruble and Bruno P. Guiard},
  journal={Neuropharmacology},
  year={2016},
  volume={105},
  pages={142-153}
}

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References

SHOWING 1-10 OF 87 REFERENCES

Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy

It is suggested that genetically determined variation in serotonin receptor genes makes a significant contribution to the efficacy of commonly prescribed antidepressant drugs.

Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.

There is a compelling case for a key role of HTR2A in the mechanism of antidepressant action, as detected in patients treated with the antidepressant citalopram.

5-HT2A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system

The blockade of the 5-HT2AR may strengthen the antidepressant-like effect of escitalopram by facilitating the enhancement of the brain NE transmission and provide support for the use of atypical antipsychotics with SSRIs as a relevant antidepressant augmentation strategy.

Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms.

There are many inconsistencies, particularly between candidate gene and genome-wide association studies, but some consistency is seen in candidate gene studies supporting established pharmacological mechanisms of antipsychotic and antidepressant response with associations of functional genetic polymorphisms in the dopamine D2 receptor and serotonin transporter and receptors.

HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese Cohort

It is suggested that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients, and it will be important to replicate and confirm these findings in other independent studies using large samples.

Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder

The finding suggests that 5-HTTLPR, STin2, H TR1A, HTR2A, TPH1 and BDNF may modulate antidepressant response.

No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression

This study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD and Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
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