Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach

@article{Qesseveur2016GeneticDO,
  title={Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach},
  author={Ga{\"e}l Qesseveur and Anne-C{\'e}cile Petit and Hai Thanh Nguyen and Lionel Dahan and Romain Colle and Samuel Rotenberg and Isabelle Seif and Pauline Robert and Denis J. David and Jean-Philippe Guilloux and Alain M. Gardier and C{\'e}line Verstuyft and Laurent Becquemont and Emmanuelle Corruble and Bruno P. Guiard},
  journal={Neuropharmacology},
  year={2016},
  volume={105},
  pages={142-153}
}
Pharmacological studies have yielded valuable insights into the role of the serotonin 2A (5-HT2A) receptor in major depressive disorder (MDD) and antidepressant drugs (ADs) response. However, it is still unknown whether genetic variants in the HTR2A gene affect the therapeutic outcome of ADs and the mechanism underlying the regulation of such response remains poorly described. In this context, a translational human-mouse study offers a unique opportunity to address the possibility that… Expand
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