Genetic drift and within-host metapopulation dynamics of HIV-1 infection.

Abstract

Most HIV replication occurs in solid lymphoid tissue, which has prominent architecture at the histological level, which separates groups of productively infected CD4(+) cells. Nevertheless, current population models of HIV assume panmixis within lymphoid tissue. We present a simple "metapopulation" model of HIV replication, where the population of infected… (More)

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Cite this paper

@article{Frost2001GeneticDA, title={Genetic drift and within-host metapopulation dynamics of HIV-1 infection.}, author={Simon D. W. Frost and M J Dumaurier and Simon Wain-Hobson and A. Brown}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2001}, volume={98 12}, pages={6975-80} }