Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru

@article{Chenet2007GeneticDO,
  title={Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru},
  author={Stella M. Chenet and Oralee H Branch and Anan{\'i}as A. Escalante and Carmen M. Lucas and David J. Bacon},
  journal={Malaria Journal},
  year={2007},
  volume={7},
  pages={93 - 93}
}
Several of the intended Plasmodium falciparum vaccine candidate antigens are highly polymorphic and could render a vaccine ineffective if their antigenic sites were not represented in the vaccine. In this study, characterization of genetic variability was performed in major B and T-cell epitopes within vaccine candidate antigens in isolates of P. falciparum from Peru. DNA sequencing analysis was completed on 139 isolates of P. falciparum collected from endemic areas of the Amazon basin in… CONTINUE READING

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