Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality

@inproceedings{Hamoudi2013GeneticDO,
  title={Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality},
  author={Meriem Hamoudi and Etienne Simon-Lori{\`e}re and Romain Gasser and Matteo Negroni},
  booktitle={Retrovirology},
  year={2013}
}
The HIV envelope (Env) promotes viral entry in the host cell. During this process, Env undergoes several conformational changes to ensure its function. At the same time, the gp120 component of Env is the protein of the virus presenting the largest genetic diversity. Understanding how the virus maintains the balance between the competing requirements for maintenance of functionality and antigenic variation of this protein is central for the comprehension of its strategies of evolution and can… CONTINUE READING

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