Genetic diversity of the gene cluster encoding longus, a type IV pilus of enterotoxigenic Escherichia coli.

@article{GmezDuarte2007GeneticDO,
  title={Genetic diversity of the gene cluster encoding longus, a type IV pilus of enterotoxigenic Escherichia coli.},
  author={Oscar G G{\'o}mez-Duarte and Sujay Chattopadhyay and Scott J. Weissman and Jorge A Gir{\'o}n and J. Kaper and Evgeni V. Sokurenko},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 24},
  pages={9145-9}
}
Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer. 

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Longus and colonization factor antigen III AC CE PT ED at P nn S ate U iv on F ebuary 12

  • O. G. Gomez-Duarte, A. Ruiz-Tagle, +4 authors J. A. Giron
  • 1999
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