Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa.

@article{Smith1993GeneticDO,
  title={Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa.},
  author={Anthony Marius Smith and Keith P. Klugman and Tracey J. Coffey and Brian G. Spratt},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 9},
  pages={1938-44}
}
Streptococcus pneumoniae (the pneumococcus) is believed to have developed resistance to penicillin by the production of altered forms of penicillin-binding proteins (PBPs) that have decreased affinity for penicillin. Sixty-eight clinical isolates of serogroup 6 and 19 pneumococci (MICs, < 0.015 to 8 micrograms/ml) were randomly selected from hospitals across South Africa which are at substantial geographic distance from each other. The polymerase chain reaction was used to isolate the… CONTINUE READING

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