Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection.

@article{Nzila2002GeneticDO,
  title={Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection.},
  author={Alexis M Nzila and Edward K Mberu and Eunice Nduati and Amanda Ross and William M. Watkins and Carol Hopkins Sibley},
  journal={International journal for parasitology},
  year={2002},
  volume={32 12},
  pages={1469-76}
}
The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after antimalarial drug treatment. However, none of the previous reports has clearly assessed the change of genetic diversity following drug treatment. In the present study, we have assessed the impact of pyrimethamine/sulfadoxine and chlorproguanil/dapsone on the genetic diversity of isolates and the… CONTINUE READING
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