Genetic diversity and function in the human cytosolic sulfotransferases

@article{Hildebrandt2007GeneticDA,
  title={Genetic diversity and function in the human cytosolic sulfotransferases},
  author={Michelle A. T. Hildebrandt and Dana P Carrington and Bianca A Thomae and Bruce W. Eckloff and Daniel J. Schaid and Vivien C. Yee and Richard M. Weinshilboum and Eric D. Wieben},
  journal={The Pharmacogenomics Journal},
  year={2007},
  volume={7},
  pages={133-143}
}
Amino-acid substitutions, which result from common nonsynonymous (NS) polymorphisms, may dramatically alter the function of the encoded protein. Gaining insight into how these substitutions alter function is a step toward acquiring predictability. In this study, we incorporated gene resequencing, functional genomics, amino-acid characterization and crystal structure analysis for the cytosolic sulfotransferases (SULTs) to attempt to gain predictability regarding the function of variant allozymes… CONTINUE READING
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