Genetic diversity and function in the human cytosolic sulfotransferases

  title={Genetic diversity and function in the human cytosolic sulfotransferases},
  author={Michelle A. T. Hildebrandt and Dana P Carrington and Bianca A Thomae and Bruce W. Eckloff and Daniel J. Schaid and Vivien C. Yee and Richard M. Weinshilboum and Eric D. Wieben},
  journal={The Pharmacogenomics Journal},
Amino-acid substitutions, which result from common nonsynonymous (NS) polymorphisms, may dramatically alter the function of the encoded protein. Gaining insight into how these substitutions alter function is a step toward acquiring predictability. In this study, we incorporated gene resequencing, functional genomics, amino-acid characterization and crystal structure analysis for the cytosolic sulfotransferases (SULTs) to attempt to gain predictability regarding the function of variant allozymes… CONTINUE READING
Highly Cited
This paper has 38 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.

Drug metabolism and disposition: the biological fate of chemicals • 2011
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 47 references

Sulfate conjugation: pharmacogenetics and pharmacogenomics

R Weinshilboum, AA Adjei
Pacifici GM, Coughtrie MW (eds). Human Cytosolic Sulfotransferases. Taylor and Francis: Boca Raton, Fl, • 2005