Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele.

@article{Qu2000GeneticDO,
  title={Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele.},
  author={W M Qu and Tatsuhiko Miyazaki and Miho Terada and L M Lu and Miyuki Nishihara and Akihisa Yamada and Shiro Mori and Yusuke Nakamura and Hiroshi Ogasawara and Chikai Yazawa and Shuichi Nakatsuru and Masato Nose},
  journal={European journal of immunology},
  year={2000},
  volume={30 7},
  pages={2027-37}
}
An MRL/MpJ strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), composed of genomes derived from LG/J, AKR/J, C3H/Di and C57BL/6J mice, develops systemic vasculitis coincidentally with other collagen diseases, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. In a genome-wide screening of the MRL background genes mediating susceptibility to collagen diseases using N2 progeny mice MRL/lpr x (MRL/lpr x C3H/lpr)F1, we previously found that each collagen disease is controlled by a… CONTINUE READING
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