Genetic dissection of theta rhythm heterogeneity in mice.

@article{Shin2005GeneticDO,
  title={Genetic dissection of theta rhythm heterogeneity in mice.},
  author={Jong-Seung Shin and Daesoo Kim and R. Bianchi and R. Wong and Hee-Sup Shin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 50},
  pages={
          18165-70
        }
}
Rhythmic oscillatory activities at the theta frequency (4-12 Hz) in the hippocampus have long-attracted attention because they have been implicated in diverse brain functions, including spatial cognition. Although studies based on pharmacology and lesion experiments suggested heterogeneity of these rhythms and their behavioral correlates, controversies are abundant on these issues. Here we show that mice harboring a phospholipase C (PLC)-beta1(-/-) mutation (PLC-beta1(-/-) mice) lack one subset… Expand
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TLDR
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Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Cav3.2 T-type voltage-gated calcium channel
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References

SHOWING 1-10 OF 88 REFERENCES
Generation of Theta and Gamma Rhythms in the Hippocampus
  • L. S. Leung
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1998
TLDR
In the behaving rat, theta rhythm was dominant during walking and rapid-eye-movement sleep, while irregular slow activity predominated during immobility and slow-wave sleep, and single cell recordings in vitro suggested that intrinsic voltage-dependent membrane potential oscillations modulate the response to a theta-frequency driving. Expand
In vivo contribution of h‐channels in the septal pacemaker to theta rhythm generation
TLDR
It is found that Ih blockade in the medial septum substantially decreased the frequency of hippocampal oscillations without changing the context in which theta occurred, i.e. specific behaviours in freely moving rats and spontaneous switching and brainstem stimulation under anaesthesia. Expand
Do septal neurons pace the hippocampal theta rhythm?
TLDR
Four models of the septo-hippocampal connections involved in theta rhythm production are reviewed as the precise roles of these projections are discussed, and in the final, consolidated model both cholinergic and GABAergic septal projection cells fire in rhythmic bursts that entrain hippocampal interneurons. Expand
Slow and fast inhibition and an H-current interact to create a theta rhythm in a model of CA1 interneuron network.
TLDR
A model is presented suggesting that individual O- LM cells, by themselves, are capable of producing a single-cell theta-frequency firing, but coupled O-LM cells are not capable of produce a coherent population theta. Expand
Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital
TLDR
Atropine-resistant activation of the cerebrum may play a role in the emission and control of normal behavior and may mediate many of the behavioral effects of centrally acting drugs such as anesthetics, tranquilizers, or stimulants. Expand
Gating of Human Theta Oscillations by a Working Memory Task
TLDR
The results suggest that theta oscillations could have an important role in organizing multi-item working memory and reveal a new phenomenon, the cognitive "gating" of a brain oscillation. Expand
Properties of carbachol-induced oscillatory activity in rat hippocampus.
TLDR
The results establish the local circuit elements and neurotransmitter receptors that contribute to carbachol-induced oscillations and indicate that carbchol- induced oscillations are fundamentally distinct from theta rhythm in vivo. Expand
Muscarinic Induction of Hippocampal Gamma Oscillations Requires Coupling of the M1 Receptor to Two Mixed Cation Currents
TLDR
In vitro gamma oscillations induced by muscarine require activation of M1 receptors on hippocampal CA3 pyramidal neurons and are absent in M1 receptor-deficient mice, unequivocally establishing a novel role for muscarinic modulation of I(h) and I(cat) in rhythmic network activity. Expand
Brainstem-diencephalo-septohippocampal systems controlling the theta rhythm of the hippocampus.
TLDR
It is demonstrated that the theta rhythm is controlled by a network of cells extending from the brainstem to the septum/hippocampus and that its disruption (electroencephalographic desynchronization) may block or temporarily suspend mnemonic processes of the hippocampus. Expand
Loss of hippocampal theta rhythm results in spatial memory deficit in the rat.
TLDR
Although rats without theta rhythm could not find their way directly to the goal, they recognized its location when they came upon it by chance, indicating a type of spatial deficit similar to that shown by hippocampally lesioned patient H.M. Expand
...
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