Genetic dissection of the function of mammalian P-glycoproteins.

@article{Borst1997GeneticDO,
  title={Genetic dissection of the function of mammalian P-glycoproteins.},
  author={Piet Borst and Alfred H Schinkel},
  journal={Trends in genetics : TIG},
  year={1997},
  volume={13 6},
  pages={217-22}
}
Mammalian P-glycoproteins are plasma membrane proteins belonging to the superfamily of ATP-binding cassette transporters. They were discovered as drug pumps in multidrug-resistant cancer cells, but are also present in many normal tissues. Genetic approaches have helped to dissect the physiological functions and mode of action of P-glycoproteins. Disruption of both genes for the drug-transporting P-glycoproteins in mice has no effect on the normal sheltered life of these mice, but renders them… CONTINUE READING

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