Genetic dissection of sexual orientation: behavioral, cellular, and molecular approaches in Drosophila melanogaster

  title={Genetic dissection of sexual orientation: behavioral, cellular, and molecular approaches in Drosophila melanogaster
  author={Daisuke Yamamoto and Hiroki Ito and Kazuko Fujitani},
  journal={Neuroscience Research},

Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating

It is suggested that sensory inputs mediated and/or processed by the tarsal receptors, suboesophageal ganglion, antennal lobe and mushroom body contribute to the regulation of male–female courtship.

Aberrant splicing and altered spatial expression patterns in fruitless mutants of Drosophila melanogaster.

It is suggested that the mutant phenotypes in fru(2, fru(3), fru(4), and fru(sat) animals are due to a failure to appropriately splice P1 transcripts, whereas the mutant phenotype of fru(1) animals is due to the reduction or absence of P1 Transcripts within specific regions of the CNS.

Genes for sexual behavior.

The mating behavior of Drosophila melanogaster is a stereotyped sequence of fixed action patterns, composed of orientation, tapping, singing, licking, attempted copulation and copulation. Mutations

The evolution of courtship behaviors through the origination of a new gene in Drosophila

It is shown that a knockout of this gene leads to increased male–male courtship in D. melanogaster, although it leaves other aspects of mating behavior unchanged.

Doublesex and the Regulation of Sexual Dimorphism in Drosophila melanogaster

The structure of the extended C-terminal dimerization domain of DSXF is described as determined by multidimensional NMR spectroscopy and contains dimer-related UBA folds similar to those defined by x-ray crystallographic studies of a truncated domain.

lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins.

It is proposed that lig may act in the nervous system to mediate the control of copulatory organs during courtship, and a set of homologous proteins in mammals suggest that Drosophila Lig belongs to a family of proteins that share five highly conserved domains.

The Drosophila Bruton’s Tyrosine Kinase (Btk) Homolog Is Required for Adult Survival and Male Genital Formation

ABSTRACT We isolated a Drosophila fickleP(ficP) mutant with a shortened copulatory duration and reduced adult-stage life span. The reduced copulatory duration is ascribable to incomplete fusion of

Conditional disruption of synaptic transmission induces male–male courtship behavior in Drosophila

  • T. Kitamoto
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
The presented strategy that can induce behavioral abnormalities by disrupting synaptic transmission in an acute and noninvasive manner will allow further exploration as to how distinct neuronal groups control sexual orientation and other aspects of reproductive behavior in Drosophila.



Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain.

It is suggested that fru functions downstream of tra in the sex-determination cascade in some neural cells and that inappropriate sexual development of these cells in the fru mutants results in altered sexual orientation of the fly.

Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster.

  • J. BeloteB. S. Baker
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
The results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.

Genetic dissection of sexual behavior in Drosophila melanogaster.

This review presents current understandings of mating behavior obtained by such molecular and cellular approaches and provides an overview of future directions of research in behavioral genetics.

Behavioral and neurobiological implications of sex-determining factors in Drosophila.

Results obtained from assessments of doublesex mutations' effects on general reproductive actions and on a particular component of the courtship sequence (male "singing" behavior) lead to the suggestion that there is a previously unrecognized branch within the sex-determination hierarchy, which controls the differentiation of the male- and female- specific phenotypes of Drosophila.

Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.

This type of screen appears to be an effective way to find new loci that may play a role in the development of the Drosophila nervous system.

Genetic feminization of brain structures and changed sexual orientation in male Drosophila

The neural basis of sexual orientation in Drosophila was studied by the production of males with regionally feminized brains, which facilitated the creation of lines with a stable pattern of feminization.

Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis.

83 recessive autosomal male-sterile mutations, generated by single P element mutagenesis in Drosophila melanogaster are described, providing the basis for a molecular genetic analysis of spermatogenesis.

Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics.

In gynandromorphs of Drosophila, a detailed examination was made of the association between male courtship behavior and the chromosomal genotype of various parts of the central nervous system. Mosaic

Female Myoblasts Can Participate in the Formation of a Male-specific Muscle in Drosophila

It is indicated that myoblasts, independently of their sexual identity, can participate in the formation of the male-specific muscle in Drosophila melanogaster.

Behavior and cytogenetics of fruitless in Drosophila melanogaster: different courtship defects caused by separate, closely linked lesions.

The fruitless (fru) courtship mutant was dissected into three defects of male reproductive behavior, which were separable as to their genetic etiologies by application of existing and newly induced