Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism

@article{Serretti2003GeneticDO,
  title={Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism},
  author={Alessandro Serretti and Francesco Benedetti and Laura Mandelli and Cristina Lorenzi and Adele Pirovano and Cristina Colombo and Enrico Smeraldi},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2003},
  volume={121B}
}
We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P = 0.0074). Other demographic and clinical features were found not related with CLOCK… Expand
Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism
  • A. Serretti, C. Cusin, +5 authors E. Smeraldi
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
TLDR
The findings may suggest that CLOCK genotype influences the time course of insomnia during antidepressant treatment, and together with previous findings on this polymorphism could lead to a further dissection of the complexity of mood disorders. Expand
Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population
TLDR
It is suggested that CLOCK may not play a major role in the pathophysiology of Japanese schizophrenia, BP and MDD patients, and it will be important to replicate and confirm these findings in other independent studies using large samples. Expand
T3111C CLOCK SINGLE NUCLEOTIDE POLYMORPHISM AND MOOD DISORDERS: A META-ANALYSIS
TLDR
A meta-analysis shows no association between rs1801260 and mood disorders (as a complete phenotype) or depression severity and points out the necessity of further research in order to better understand the underlying biological machinery of circadian dysfunction in subjects affected by mood disorders. Expand
Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
  • F. Benedetti, S. Dallaspezia, +5 authors E. Smeraldi
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
TLDR
O Ongoing lithium treatment significantly interacted with CLOCK 3111 T/C SNP (rs1801260) by enhancing activity levels in the evening and reducing the differences among genotype groups. Expand
Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia
TLDR
Evidence for association between specific SNPs at the circadian gene loci and BD1 is tentative, and additional studies using larger samples are required to evaluate the associations reported here. Expand
The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis
The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) hasExpand
3111T/C CLOCK GENE POLYMORPHISM IS NOT ASSOCIATED WITH SLEEP DISTURBANCES IN UNTREATED DEPRESSED PATIENTS
TLDR
The present findings did not support the hypothesis of an effect of the T3111C CLOCK variant on sleep disturbances in major depressive disorder, and further analysis of clock machinery will clarify the contribution of clock genes to the maintenance of mental health. Expand
CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients
TLDR
The results indicate that CLOCK genotype may be a predictor of fluvoxamine treatment response in Japanese MDD, although the sample size was small, and a replication study using larger samples may be required for conclusive results. Expand
CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: A preliminary study
TLDR
The results suggest that the T3111C polymorphism of the CLOCK gene is associated with schizophrenia. Expand
The Relationship Between Tryptophan Hydroxylase-2 Gene with Primary Insomnia and Depressive Symptoms in the Han Chinese Population
TLDR
The tryptophan hydroxylase-2 gene polymorphism rs4290270 may not be a susceptibility locus for primary insomnia in Han Chinese, but it may be a marker of depressive symptoms. Expand
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