Genetic dissection of peroxisome-associated matrix protein degradation in Arabidopsis thaliana.

@article{Burkhart2013GeneticDO,
  title={Genetic dissection of peroxisome-associated matrix protein degradation in Arabidopsis thaliana.},
  author={Sarah E. Burkhart and Matthew J. Lingard and Bonnie Bartel},
  journal={Genetics},
  year={2013},
  volume={193 1},
  pages={125-41}
}
Peroxisomes are organelles that sequester certain metabolic pathways; many of these pathways generate H(2)O(2), which can damage proteins. However, little is known about how damaged or obsolete peroxisomal proteins are degraded. We exploit developmentally timed peroxisomal content remodeling in Arabidopsis thaliana to elucidate peroxisome-associated protein degradation. Isocitrate lyase (ICL) is a peroxisomal glyoxylate cycle enzyme necessary for early seedling development. A few days after… CONTINUE READING
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