Genetic dissection of myelin galactolipid function.

@article{Dupree1999GeneticDO,
  title={Genetic dissection of myelin galactolipid function.},
  author={Jeffrey L Dupree and Brian Popko},
  journal={Journal of neurocytology},
  year={1999},
  volume={28 4-5},
  pages={
          271-9
        }
}
The roles that the myelin galactolipids galactocerebroside (GalC) and sulfatide play in cellular differentiation, myelin formation and maintenance have been investigated for nearly 3 decades. During that time the primary approach has been to perturb lipid activity using antibodies and chemical agents in artificial systems. Recently, the isolation of the gene that encodes UDP-galactose:ceramide galactosyltransferase (CGT), the enzyme that catalyzes an essential step in the synthetic pathway of… CONTINUE READING
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