Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.

  title={Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.},
  author={Chandra Mohan and Laurence M Morel and Pingar Yang and Haruko Watanabe and Byron P. Croker and Gary G Gilkeson and Edward K. Wakeland},
  journal={The Journal of clinical investigation},
  volume={103 12},
Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of mice. Our previous work has shown that B6.NZMc1 mice, congenic for Sle1, exhibit loss of tolerance to chromatin but do not develop any pathogenic autoantibodies or disease. B6.NZMc7 mice, congenic for Sle3, exhibit low-grade polyclonal B- and T-cell activation, elevated CD4/CD8 ratios, and mildly penetrant glomerulonephritis. In contrast to these monocongenics, the present study reveals that B6.NZMc1… CONTINUE READING


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