Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors

@article{Peretz1994GeneticDO,
  title={Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors},
  author={Asher Peretz and C H Sandler and Kuno Kirschfeld and Roger C. Hardie and Baruch Minke},
  journal={The Journal of General Physiology},
  year={1994},
  volume={104},
  pages={1057 - 1077}
}
Invertebrate photoreceptors use the inositol-lipid signaling cascade for phototransduction. A useful approach to dissect this pathway and its regulation has been provided by the isolation of Drosophila visual mutants. We measured extracellular changes of Ca2+ [delta Ca2+]o in Drosophila retina using Ca(2+)-selective microelectrodes in both the transient receptor potential (trp) mutant, in which the calcium permeability of the light-sensitive channels is greatly diminished and in the… CONTINUE READING