Genetic dissection of an amygdala microcircuit that gates conditioned fear

  title={Genetic dissection of an amygdala microcircuit that gates conditioned fear},
  author={Wulf Haubensak and Prabhat S. Kunwar and Haijiang Cai and St{\'e}phane Ciocchi and Nicholas R Wall and Ravikumar Ponnusamy and Jonathan Biag and Hong-wei Dong and Karl Deisseroth and Edward M. Callaway and Michael S Fanselow and Andreas L{\"u}thi and David J. Anderson},
The role of different amygdala nuclei (neuroanatomical subdivisions) in processing Pavlovian conditioned fear has been studied extensively, but the function of the heterogeneous neuronal subtypes within these nuclei remains poorly understood. Here we use molecular genetic approaches to map the functional connectivity of a subpopulation of GABA-containing neurons, located in the lateral subdivision of the central amygdala (CEl), which express protein kinase C-δ (PKC-δ). Channelrhodopsin-2… CONTINUE READING
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