Genetic dissection of Pax6 dosage requirements in the developing mouse eye.

@article{DavisSilberman2005GeneticDO,
  title={Genetic dissection of Pax6 dosage requirements in the developing mouse eye.},
  author={Noa Davis-Silberman and Tomer Kalich and Varda Oron-Karni and Till Marquardt and Markus Kroeber and Ernst R Tamm and Ruth Ashery-Padan},
  journal={Human molecular genetics},
  year={2005},
  volume={14 15},
  pages={2265-76}
}
Haploinsufficiency of the transcription factor Pax6/PAX6 has been implicated in a number of congenital eye disorders in humans and mice, such as aniridia and Small-eye, which affect the development and function of the lens, cornea, anterior eye segment and neuroretina. However, the widespread distribution of Pax6/PAX6 protein within the developing and adult eye preclude the identification and direct study of the ocular tissues affected by a reduction in Pax6/PAX6 dosage. Here, we employed Cre… CONTINUE READING
39 Citations
61 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…