Genetic dissection of Drosophila adenylate cyclase.

  title={Genetic dissection of Drosophila adenylate cyclase.},
  author={Margaret S. Livingstone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={82 17},
The Drosophila learning mutant rutabaga is missing calcium/calmodulin activation of adenylate cyclase (EC4.6.1.1). The mutation was mapped at a finer resolution to X chromosome bands 12F5-7. By comparing wild-type and mutant cyclase activities, the relative responsiveness of the calcium-sensitive and calcium-insensitive components to different ligands could be determined; the calcium-sensitive fraction of the total cyclase activity was significantly less responsive to guanyl nucleotides and… CONTINUE READING

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