Genetic dissection of Alzheimer disease, a heterogeneous disorder.

  title={Genetic dissection of Alzheimer disease, a heterogeneous disorder.},
  author={Gerard D. Schellenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 19},
The genetics of Alzheimer disease (AD) are complex and not completely understood. Mutations in the amyloid precursor protein gene (APP) can cause early-onset autosomal dominant AD. In vitro studies indicate that cells expressing mutant APPs overproduce pathogenic forms of the A beta peptide, the major component of AD amyloid. However, mutations in the APP gene are responsible for 5% or less of all early-onset familial AD. A locus on chromosome 14 is responsible for AD in other early-onset AD… CONTINUE READING


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