Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease

@article{Rouillard2018GeneticDO,
  title={Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease},
  author={Claude Rouillard and Joanie Baillargeon and Brigitte Paquet and Michel St-Hilaire and Daniel L{\'e}vesque},
  journal={Experimental Neurology},
  year={2018},
  volume={304},
  pages={143-153}
}
  • Claude Rouillard, Joanie Baillargeon, +2 authors Daniel Lévesque
  • Published in Experimental Neurology 2018
  • Biology, Medicine
  • ABSTRACT Parkinson's disease (PD) is an idiopathic progressive neurodegenerative disorder characterized by the loss of midbrain dopamine neurons. Levodopa (l‐dopa) is the main pharmacological approach to relieve PD motor symptoms. However, chronic treatment with l‐Dopa is inevitably associated with the generation of abnormal involuntary movements (l‐Dopa‐induced dyskinesia). We have previously shown that Nr4a1 (Nur77), a transcription factor of the nuclear receptor family, is closely associated… CONTINUE READING

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