Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood.

@article{Kojima2010GeneticDO,
  title={Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood.},
  author={Nobuhiko Kojima and Kenji Hanamura and Hiroyuki Yamazaki and Toshio Ikeda and Shigeyoshi Itohara and Tomoaki Shirao},
  journal={Neuroscience},
  year={2010},
  volume={165 1},
  pages={138-50}
}
Dendritic spines are postsynaptic structures at excitatory synapses that play important roles in synaptic transmission and plasticity. Dendritic spine morphology and function are regulated by an actin-based cytoskeletal network. Drebrin A, an adult form of drebrin, is an actin-binding protein in dendritic spines, and its decrease is purportedly concerned with synaptic dysfunction in Alzheimer's disease. Rapid conversion of drebrin E, an embryonic form of drebrin, to drebrin A occurs in parallel… CONTINUE READING

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