Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.

@article{Park2001GeneticDO,
  title={Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.},
  author={Ben Ho Park and Bert Vogelstein and Kenneth W. Kinzler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 5},
  pages={2598-603}
}
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPARdelta isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC)/beta-catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPARdelta null cell line was created by targeted homologous recombination. When inoculated as xenografts in nude mice, PPARdelta -/- cells exhibited a… CONTINUE READING

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