Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice.

@article{Liu2001GeneticDI,
  title={Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice.},
  author={Xiang Yu Liu and Howard K. Gershenfeld},
  journal={Biological psychiatry},
  year={2001},
  volume={49 7},
  pages={575-81}
}
BACKGROUND The tail suspension test (TST) is a simple screening test for the behavioral effects of antidepressants in rodents. This experiment investigated the interindividual differences in responses to stressful situations measured by duration of immobility in the TST and the effects of imipramine (30 mg/kg intraperitoneally) in reducing immobility among 11 inbred strains of mice. The 11 inbred strains were 129S6/SvEvTac, A/J, AKR/J, Balb/cJ, C3H/HeJ, C57BL/6J, DBA/2J, FVB/NJ, NMRI, SencarA… CONTINUE READING

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