Genetic differences in the frequency of the hinge variants of porcine IgA is breed dependent.

@article{Navarro2000GeneticDI,
  title={Genetic differences in the frequency of the hinge variants of porcine IgA is breed dependent.},
  author={Pedro Navarro and Ronald K. Christenson and G Ekhardt and Bruce Bosworth and Joan K. Lunney and Miriam Rothschild and Joachim Lemke and John E. Butler},
  journal={Veterinary immunology and immunopathology},
  year={2000},
  volume={73 3-4},
  pages={
          287-95
        }
}
The distribution of the IgA(a) and IgA(b) alleles of porcine IgA in over 160 randomly-selected animals revealed an abundance of heterozygotes but only two b/b homozygotes. Since the IgA(b) allotype is a splice site mutant lacking two-thirds of the hinge, this study tests the hypothesis that pigs with this genotype may be at a selective disadvantage while heterozygous individuals may be at some advantage. This hypothesis was tested by collecting data on 374 animals of known breed and often… CONTINUE READING

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