Genetic differences in the effects of competitive and non-competitive NMDA receptor antagonists on locomotor activity in mice

@article{Liljequist1991GeneticDI,
  title={Genetic differences in the effects of competitive and non-competitive NMDA receptor antagonists on locomotor activity in mice},
  author={Sture Liljequist},
  journal={Psychopharmacology},
  year={1991},
  volume={104},
  pages={17-21}
}
The effects of non-competitive (MK-801, phencyclidine, and ketamine) and competitive (CGP 39551, CGS 19755, and NPC 12626) N-methyl-d-aspartate (NMDA) receptor antagonists on locomotor activity in inbred CBA and C57, and in outbred NMRI mice were examined. Administration of the non-competitive NMDA antagonists produced a dose-dependent increase in well-coordinated locomotor activity at lower doses, followed by a bizarre behavioral syndrome (head weaving, body rolling, rotations, ataxia) after… CONTINUE READING