Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.

@article{Nebert1981GeneticDI,
  title={Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.},
  author={D. Nebert},
  journal={Environmental Health Perspectives},
  year={1981},
  volume={39},
  pages={11 - 22}
}
  • D. Nebert
  • Published 1981
  • Biology, Medicine
  • Environmental Health Perspectives
The Ah locus represents a complex "cluster" of genese controlling the induction of numerous drug-metabolizing enzyme "activities" by polycyclic aromatic compounds. Allelic differences at the Ah locus are reflected in the large differences in inducibility of cytochrome P1-450 and benzo[a]pyrene metabolism in numerous tissues when the mice receive the chemical daily in their diet. This experimental model system offers to the hematologist and clinical pharmacologist a means to study genetic… Expand
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