Genetic differences in opiate receptor concentration and sensitivity to ethanol's effects.

@article{Yirmiya1989GeneticDI,
  title={Genetic differences in opiate receptor concentration and sensitivity to ethanol's effects.},
  author={Raz Yirmiya and A. Newman Taylor},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={33 4},
  pages={793-6}
}
The hypothesis that genetic differences in opiate receptor concentration are involved in determining the sensitivity to some of the effects of alcohol was studied by comparing the hypothermic and analgesic effects of ethanol in four strains of mice that can be divided into three groups on the basis of their brain opiate receptor concentration: high (CXBH), low (CXBK) and intermediate (C57BL/6By and BALB/cBy). In the first experiment, animals within each strain were injected with either saline… CONTINUE READING

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The hypothesis that genetic differences in opiate receptor concentration are involved in determining the sensitivity to some of the effects of alcohol was studied by comparing the hypothermic and analgesic effects of ethanol in four strains of mice that can be divided into three groups on the basis of their brain opiate receptor concentration : high ( CXBH ) , low ( CXBK ) and intermediate ( C57BL/6By and BALB / cBy ) .
These results suggest that the hypothermic and analgesic effects of ethanol are at least partly mediated by opiate receptors and are correlated with genetic differences in opiate receptor concentration .
The hypothesis that genetic differences in opiate receptor concentration are involved in determining the sensitivity to some of the effects of alcohol was studied by comparing the hypothermic and analgesic effects of ethanol in four strains of mice that can be divided into three groups on the basis of their brain opiate receptor concentration : high ( CXBH ) , low ( CXBK ) and intermediate ( C57BL/6By and BALB / cBy ) .
These results suggest that the hypothermic and analgesic effects of ethanol are at least partly mediated by opiate receptors and are correlated with genetic differences in opiate receptor concentration .
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