Genetic differences in drug metabolism associated with ocular toxicity.

@article{Shichi1982GeneticDI,
  title={Genetic differences in drug metabolism associated with ocular toxicity.},
  author={Hitoshi Shichi and Daniel W. Nebert},
  journal={Environmental Health Perspectives},
  year={1982},
  volume={44},
  pages={107 - 117}
}
The tissue localization and subcellular distribution of drug-metabolizing enzymes in the eye are described. With the use of inbred strains of mice, the [Ah] complex is shown to be an important experimental system for probing genetic differences in drug metabolism and related drug toxicities. Although the genetic system described in detail here involves mice… CONTINUE READING