Genetic differences between BCG substrains.

  title={Genetic differences between BCG substrains.},
  author={Yansheng Zhang and Richard J. Wallace and Gerald H Mazurek},
  journal={Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  volume={76 1},
SETTING University-affiliated Mycobacteriology Reference Laboratory. OBJECTIVE To determine the genetic differences of 25 BCG isolates representing 16 referenced substrains. DESIGN Non-randomized, observational study based on the visual comparison of the large restriction fragment (LRF) patterns created by digesting each BCG isolate's DNA with an infrequent cutting restriction endonuclease (DraI, AsnI, XbaI or SpeI) and separating the resultant DNA fragments with pulsed field gel… CONTINUE READING
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