Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.

@article{Gould2004GeneticDO,
  title={Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18.},
  author={Karen A. Gould and Martin Tochacek and Beverly S. Schaffer and Tanya M Reindl and Clare R. Murrin and Cynthia M. Lachel and Eric A Vanderwoude and Karen L. Pennington and Lisa A. Flood and Kimberly K. Bynot{\'e} and Jane L. Meza and Michael A. Newton and James D Shull},
  journal={Genetics},
  year={2004},
  volume={168 4},
  pages={2113-25}
}
Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segregate as an incompletely dominant trait… CONTINUE READING