Genetic determination of cartilaginous metaplasia in mouse aorta.

  title={Genetic determination of cartilaginous metaplasia in mouse aorta.},
  author={Jian-hua Qiao and Michael C. Fishbein and Linda L. Demer and Aldons J. Lusis},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={15 12},
Calcification frequently occurs in atherosclerotic plaques in humans, but the cellular and genetic factors contributing to this pathological trait are unknown. We previously reported that the arterial calcification among inbred strains is genetically determined, and we now report that cartilaginous metaplasia, associated with the presence of arterial chondrocytes that express type II collagen, may underlie this calcification. Both uncalcified and calcified cartilaginous metaplasia were often… CONTINUE READING


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