Genetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects.

@article{Paternoster2009GeneticDO,
  title={Genetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects.},
  author={Lavinia Paternoster and Wanting Chen and Cathie L. M. Sudlow},
  journal={Stroke},
  year={2009},
  volume={40 6},
  pages={2020-6}
}
BACKGROUND AND PURPOSE White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candidate genes and WMH. We aimed to evaluate the evidence for… CONTINUE READING