Genetic determinants of the metabolic syndrome

@article{Pollex2006GeneticDO,
  title={Genetic determinants of the metabolic syndrome},
  author={Rebecca L. Pollex and Robert A. Hegele},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  year={2006},
  volume={3},
  pages={482-489}
}
  • R. Pollex, R. Hegele
  • Published 2006
  • Medicine
  • Nature Clinical Practice Cardiovascular Medicine
The metabolic syndrome is a commonly encountered clinical phenotype presenting as concurrent metabolic abnormalities, including central obesity, dysglycemia, dyslipidemia, and hypertension. Several definitions exist, and it is debated whether or not the clustered risk factors impart a higher cardiovascular risk than the simple sum of the individual components. Nevertheless, the concept of a metabolic syndrome has proven helpful in emphasizing the importance of obesity, insulin resistance and… Expand
Genetics of metabolic syndrome: Is there a role for phenomics?
TLDR
Evidence that MetS has a genetic component and the potential applicability of clinical phenomics for the genetic evaluation of MetS is reviewed using the example of hierarchical cluster analysis of phenotypic components of lipodystrophy syndromes, which serve as monogenic models of Mets. Expand
The metabolic syndrome.
TLDR
The "metabolic syndrome" is a clustering of components that reflect overnutrition, sedentary lifestyles, and resultant excess adiposity that is associated with an approximate doubling of cardiovascular disease risk and a 5-fold increased risk for incident type 2 diabetes mellitus. Expand
Insulin Resistance, Diabetes, and Cardiovascular Risk in Women and the Paradigm of the Polycystic Ovary Syndrome
TLDR
Reducing androgen levels in abdominally obese women with or without PCOS may represent a clinical challenge for treatment and, possibly, for preventive intervention strategies. Expand
A REVIEW ON METABOLIC SYNDOME: BIOCHEMICAL INVESTIGATIONS
TLDR
It is concluded that the main and prevalent risk factors for the pathophysiology of Metabolic Syndrome are Insulin resistant, abdominal obesity. Expand
Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes.
TLDR
The results suggest that among the Han Chinese population, several SNPs increase the risk of severe MetS in T2D subjects, and further study in a large population should be conducted. Expand
Chapter 15 – Metabolic Syndrome
TLDR
Meta-analysis of public GWAS data and risk-score analysis are revealing the role of common single-nucleotide polymorphism genotypes in MetS pathophysiology, making it a fascinating complex trait. Expand
Metabolic syndrome a widespread threatening condition; risk factors, diagnostic criteria, therapeutic options, prevention and controversies: an overview.
TLDR
Diagnosis guidelines are establishing the metabolic syndrome diagnostic when three of five conditions are met three of the following five conditions: fasting glucose, high blood pressure, abnormal high fasting plasma glucose, elevated serum triglycerides and low HDL (high-density cholesterol) level. Expand
The metabolic syndrome
TLDR
The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome. Expand
Genes and Gene–Environment Interactions in the Pathogenesis of Obesity and the Metabolic Syndrome
TLDR
How the authors' genes, alone and in combination with the environment, can give rise to obesity, the metabolic syndrome and diabetes is discussed. Expand
The Inter-Related Biomarkers of Cardio-Metabolic and Renal Disease
TLDR
This work was the first to estimate the heritability of renal function biomarkers and metabolic syndrome related traits among an African ancestry population living in the Caribbean, and suggests a promising biomarker for both renal function and cardiovascular disease. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 65 REFERENCES
Genetic and physiological insights into the metabolic syndrome.
  • R. Hegele, R. Pollex
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2005
TLDR
To define etiology, pathogenesis and expression of MetS, patients are studied, specifically Canadian families and communities and FPLD seems to be a useful monogenic model of metS. Expand
Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans.
TLDR
This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome. Expand
The glucocorticoid receptor gene and its association to metabolic syndrome.
TLDR
Although several other mutations in the GR gene have been postulated as being relevant to the progression to type 2 diabetes and cardiovascular diseases, conflicting results makes it difficult to determine exactly what effect these GR variations have on metabolic syndrome incidence and progression. Expand
The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes.
The term "metabolic syndrome" refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance. Since theExpand
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.
TLDR
Pedigree-based analysis using a variance components linkage model demonstrated a quantitative trait locus (QTL) on chromosome 3 (3q27) strongly linked to six traits representing these fundamental phenotypes, and candidate genes likely to influence two biologic precursor pathways of the metabolic syndrome are identified. Expand
Association of NOS3 gene with metabolic syndrome in hypertensive patients.
TLDR
A role of the NOS3 gene in the pathogenesis of metabolic syndrome in hypertensive patients is suggested and a novel FRET system coupled to real time PCR is designed to perform sample genotyping. Expand
Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients
TLDR
The results propose several new candidate genes for the metabolic syndrome and suggest that the genetic basis of this syndrome may be strongly modified by gender. Expand
Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study.
TLDR
Nonparametric linkage analysis provided evidence for linkage of metabolic syndrome to 1q23-q31 (D1S518; logarithm of odds [LOD] 1.6) with significant site heterogeneity, contributing to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes. Expand
Lack of association between certain candidate gene polymorphisms and the metabolic syndrome.
TLDR
It is suggested that among a large sample of French men and women, the above named SNPs in UCP3, FATP1, TNF-alpha, LEP, and GNB3 genes are not major contributors to the MS risk. Expand
The ACE insertion/deletion polymorphism is not associated with the metabolic syndrome (WHO Definition) in Brazilian type 2 diabetic patients.
TLDR
The authors found that patients with MS were more often carriers of the D allele (DD/ID) than the patients without the MS (58 vs. 42%, P < 0.01). Expand
...
1
2
3
4
5
...