Genetic determinants of the homocysteine level.

  title={Genetic determinants of the homocysteine level.},
  author={Gere Sunder-Plassmann and Manuela F{\"o}dinger},
  journal={Kidney international. Supplement},
Elevated total homocysteine (tHcy) plasma concentrations indicate folate and/or vitamin B12 deficiency and are associated with cardiovascular disease and neural tube defects. Evidence has accumulated that folate-, vitamin B12-, and Hcy-metabolism are under genetic control. Because Hcy metabolism is impaired in renal failure, MTHFR 677 C>T, GCP2 1561C>T… CONTINUE READING