Genetic determinants of response to clopidogrel and cardiovascular events.

@article{Simon2009GeneticDO,
  title={Genetic determinants of response to clopidogrel and cardiovascular events.},
  author={Tabassome Simon and C{\'e}line Verstuyft and Murielle Mary-Krause and Lina Quteineh and Elodie Drouet and Nicolas F. Meneveau and Ph. Gabriel Steg and Jean Ferri{\`e}res and Nicolas Danchin and Laurent Becquemont},
  journal={The New England journal of medicine},
  year={2009},
  volume={360 4},
  pages={
          363-75
        }
}
BACKGROUND Pharmacogenetic determinants of the response of patients to clopidogrel contribute to variability in the biologic antiplatelet activity of the drug. The effect of these determinants on clinical outcomes after an acute myocardial infarction is unknown. METHODS We consecutively enrolled 2208 patients presenting with an acute myocardial infarction in a nationwide French registry and receiving clopidogrel therapy. We then assessed the relation of allelic variants of genes modulating… CONTINUE READING

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