Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

@article{Athanasiadis2013GeneticDO,
  title={Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.},
  author={G. Athanasiadis and M. Sabater-Lleal and A. Buil and J. Souto and M. Borrell and M. Lathrop and H. Watkins and L. Almasy and A. Hamsten and J. M. Soria},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2013},
  volume={11 3},
  pages={
          521-8
        }
}
  • G. Athanasiadis, M. Sabater-Lleal, +7 authors J. M. Soria
  • Published 2013
  • Biology, Medicine
  • Journal of thrombosis and haemostasis : JTH
  • BACKGROUND β2 -Glycoprotein I (β2 -GPI), also designated apolipoprotein H, is a 50-kDa protein that circulates in blood at high concentrations, playing important roles in autoimmune diseases, hemostasis, atherogenesis, and angiogenesis, as well as in host defense against bacteria and in protein/cellular waste removal. Plasma β2 -GPI levels have a significant genetic component (heritability of ~ 80%). OBJECTIVES To present the results of a genome-wide association study for plasma β2 -GPI… CONTINUE READING
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