Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

@article{Athanasiadis2013GeneticDO,
  title={Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.},
  author={Georgios Athanasiadis and Maria Sabater-Lleal and Alfonso Buil and Juan Carlos Souto and Marc Borrell and Mark Lathrop and Hugh Watkins and Lee Almasy and Anders Hamsten and Jos{\'e} Manuel Soria},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2013},
  volume={11 3},
  pages={521-8}
}
BACKGROUND β2 -Glycoprotein I (β2 -GPI), also designated apolipoprotein H, is a 50-kDa protein that circulates in blood at high concentrations, playing important roles in autoimmune diseases, hemostasis, atherogenesis, and angiogenesis, as well as in host defense against bacteria and in protein/cellular waste removal. Plasma β2 -GPI levels have a significant genetic component (heritability of ~ 80%). OBJECTIVES To present the results of a genome-wide association study for plasma β2 -GPI… CONTINUE READING