Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.

@article{Moayyeri2014GeneticDO,
  title={Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.},
  author={Alireza Moayyeri and Yi-Hsiang Hsu and David Karasik and Karol Estrada and Su-mei Xiao and Carrie M Nielson and Priya Srikanth and Sylvie K Giroux and Scott G. Wilson and Hou-Feng Zheng and Albert Vernon Smith and Stephen R Pye and Paul J Leo and Alexander Teumer and Joo-Yeon Hwang and C Ohlsson and F. Joseph Covert McGuigan and Ryan L. Minster and Caroline Hayward and Jos{\'e} M Olmos and Leo-Pekka Lyytik{\"a}inen and Joshua R Lewis and Karin M A Swart and Laura Masi and Christopher Oldmeadow and Elizabeth G. Holliday and Sulin Cheng and Natasja M. van Schoor and Nicholas C. W. Harvey and Marcin Kruk and M FabioladelGreco and Wilmar Igl and Olivia Trummer and Efi Grigoriou and Robert L Luben and Ching-Ti Liu and Yanhua Zhou and Ling Oei and Carolina Medina-Gomez and Joseph Zmuda and Gregory J Tranah and Suzanne J. Brown and Frances M. K. Williams and Nicole Soranzo and J{\'o}hanna Jakobsd{\'o}ttir and Kristin Siggeirsdottir and Kate L. Holliday and Anke Hannemann and Min Jin Go and Melissa J Garcia and Ozren Pola{\vs}ek and Marika M.L. Laaksonen and Kun Zhu and Anke W. Enneman and Mark McEvoy and Roseanne Peel and Pak C. Sham and Maciej Jaworski and {\AA}sa Johansson and Andrew A Hicks and Pawel Pludowski and Rodney Scott and Rosalie A. M. Dhonukshe-Rutten and Nathalie van der Velde and Mika K{\"a}h{\"o}nen and Jorma S. A. Viikari and Harri Siev{\"a}nen and Olli T. Raitakari and Jes{\'u}s Gonz{\'a}lez-Mac{\'i}as and Jos{\'e} Luis Mart{\'i}nez Hern{\'a}ndez and D. D. Mellstr{\"o}m and Osten Ljunggren and Yoon Shin Cho and Uwe Voelker and Matthias Nauck and Georg Homuth and Henry V{\"o}lzke and Robin Haring and Matthew A Brown and Eugene V. McCloskey and Geoffrey Charles Nicholson and Richard Eastell and John A. Eisman and Graeme Jones and Ian R Reid and Elaine M. Dennison and John Dennis Wark and Steven Boonen and Dirk Vanderschueren and Frederick C. W. Wu and Thor Aspelund and J Brent Richards and Doug Bauer and Albert Hofman and Kay-tee Khaw and George V. Z. Dedoussis and Barbara Obermayer-Pietsch and Ulf Gyllensten and Peter P. Pramstaller and Roman S. Lorenc and Cyrus Cooper and Annie Wai Chee Kung and P J A Lips and Markku Al{\'e}n and John Attia and Maria Luisa Brandi and Lisette C. P. G. M. de Groot and Terho Lehtim{\"a}ki and Jos{\'e} A Riancho and Harry Campbell and Yongmei Liu and T. B. Harris and Kristina E {\AA}kesson and Magnus Karlsson and Jong-Young Lee and Henri Wallaschofski and Emma L. Duncan and T W O'neill and Vilmundur Gudnason and Tim D. Spector and François Rousseau and Eric S. Orwoll and Steve Cummings and Nicholas J Wareham and Fernando Rivadeneira and Andr{\'e} G. Uitterlinden and Richard L Prince and Douglas P Kiel and Jonathan Reeve and Stephen K Kaptoge},
  journal={Human molecular genetics},
  year={2014},
  volume={23 11},
  pages={3054-68}
}
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts… CONTINUE READING

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In combined random effects , meta - analysis of the discovery and replication cohorts , nine single nucleotide polymorphisms ( SNPs ) had genome - wide significant ( P < 5 × 10(-8 ) ) associations with heel bone properties .
In combined random effects , meta - analysis of the discovery and replication cohorts , nine single nucleotide polymorphisms ( SNPs ) had genome - wide significant ( P < 5 × 10(-8 ) ) associations with heel bone properties .
In combined random effects , meta - analysis of the discovery and replication cohorts , nine single nucleotide polymorphisms ( SNPs ) had genome - wide significant ( P < 5 × 10(-8 ) ) associations with heel bone properties .
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