Genetic determinants of hair, eye and skin pigmentation in Europeans

  title={Genetic determinants of hair, eye and skin pigmentation in Europeans},
  author={P. Sulem and D. Gudbjartsson and S. Stacey and A. Helgason and T. Rafnar and K. Magnusson and A. Manolescu and A. K{\'a}rason and A. P{\'a}lsson and G. Thorleifsson and Margret Jakobsdottir and S. Steinberg and S. Pálsson and F. Jonasson and B. Sigurgeirsson and K. Thorisdottir and R. Ragnarsson and K. R. Benediktsdottir and K. Aben and L. Kiemeney and J. Olafsson and J. Gulcher and Augie Kong and U. Thorsteinsdottir and K. Stef{\'a}nsson},
  journal={Nature Genetics},
  • P. Sulem, D. Gudbjartsson, +22 authors K. Stefánsson
  • Published 2007
  • Biology, Medicine
  • Nature Genetics
  • Hair, skin and eye colors are highly heritable and visible traits in humans. [...] Key Method We carried out a genome-wide association scan for variants associated with hair and eye pigmentation, skin sensitivity to sun and freckling among 2,986 Icelanders. We then tested the most closely associated SNPs from six regions—four not previously implicated in the normal variation of human pigmentation—and replicated their association in a second sample of 2,718 Icelanders and a sample of 1,214 Dutch. The SNPs from…Expand Abstract
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