Genetic determinants of cancer metastasis

@article{Nguyen2007GeneticDO,
  title={Genetic determinants of cancer metastasis},
  author={Don X Nguyen and Joan Massagu{\'e}},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={341-352}
}
Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare tumour cells that overcame stringent physiological barriers as they separated from their original environment and developmental fate. This phenomenon brings into focus long-standing questions about the stage at which cancer cells acquire metastatic abilities, the relationship of metastatic cells to their tumour of origin, the basis for metastatic tissue tropism, the nature of metastasis predisposition… 
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References

SHOWING 1-10 OF 142 REFERENCES
Cancer Metastasis: Building a Framework
New signals from the invasive front
TLDR
A large number of molecular pathways and cellular mechanisms that underlie the multistage process of metastasis formation, including tumour invasion, tumour-cell dissemination through the bloodstream or the lymphatic system, colonization of distant organs and, finally, fatal outgrowth of metastases are identified.
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
TLDR
Findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations.
Selection of successive tumour lines for metastasis.
  • I. Fidler
  • Medicine, Biology
    Nature: New biology
  • 1973
TLDR
The pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or lymphatics by cells originating from a primary cancer, and most tumour emboli are initially arrested in the first capillary bed encountered, but some recirculate and are trapped in other organs.
A progression puzzle.
TLDR
This model of tumour progression carries with it a striking similarity to darwinian evolution within the microcosm of living tissues, in which the units of selection are individual cells.
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TLDR
It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.
The clonal evolution of tumor cell populations.
TLDR
Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
A multigenic program mediating breast cancer metastasis to bone.
Metastasis suppressors alter the signal transduction of cancer cells
  • P. Steeg
  • Biology, Medicine
    Nature Reviews Cancer
  • 2003
TLDR
Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified.
Evolutionary biology of cancer.
...
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