Genetic determinants of cancer metastasis

  title={Genetic determinants of cancer metastasis},
  author={Don X Nguyen and Joan Massagu{\'e}},
  journal={Nature Reviews Genetics},
Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare tumour cells that overcame stringent physiological barriers as they separated from their original environment and developmental fate. This phenomenon brings into focus long-standing questions about the stage at which cancer cells acquire metastatic abilities, the relationship of metastatic cells to their tumour of origin, the basis for metastatic tissue tropism, the nature of metastasis predisposition… 
Tracing the origins of metastasis
  • D. Nguyen
  • Biology, Medicine
    The Journal of pathology
  • 2011
There is a renewed conceptual and technological focus on characterizing the cellular and genetic heterogeneity within tumours, to ultimately trace the origins of metastatic cells in different cancers.
Determinants of Organotropic Metastasis
The spread of cancer from a primary tumor to distant organ sites is the most devastating aspect of malignancy and recent work and new experimental models of metastatic organotropism are uncovering crucial details of how malignant cells metastasize to specific tissues.
Microenvironmental regulation of metastasis
Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
The Biology of Cancer Metastasis
This chapter summarizes current concepts of dissemination and metastasis and the role of microenvironmental as well as systemically acting factors in these processes and reviews recent research on genotypes and phenotypes of early disseminated cancer cells.
Evolution and dynamics of pancreatic cancer progression
This review summarizes current knowledge of the genetics of pancreatic cancer from its initiation within a normal cell until the time that is has disseminated to distant organs, many features of which can be extrapolated to other solid tumor types.
Molecular principles of metastasis: a hallmark of cancer revisited
The authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.
Pathobiology of cancer metastasis: a short account
The analogies between some of the genetic programs of normal stem cells, and of cancer cells participating in the process of metastasis are highlighted.
Prerequisite Genetic Traits for Metastasis
The amplification and mutation of oncogenes in primary tumors, together with the selective pressures of the tumor microenvironment play a key role in the formation of metastasis.


Cancer Metastasis: Building a Framework
New signals from the invasive front
A large number of molecular pathways and cellular mechanisms that underlie the multistage process of metastasis formation, including tumour invasion, tumour-cell dissemination through the bloodstream or the lymphatic system, colonization of distant organs and, finally, fatal outgrowth of metastases are identified.
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations.
Selection of successive tumour lines for metastasis.
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  • Medicine, Biology
    Nature: New biology
  • 1973
The pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or lymphatics by cells originating from a primary cancer, and most tumour emboli are initially arrested in the first capillary bed encountered, but some recirculate and are trapped in other organs.
A progression puzzle.
This model of tumour progression carries with it a striking similarity to darwinian evolution within the microcosm of living tissues, in which the units of selection are individual cells.
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.
The clonal evolution of tumor cell populations.
Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
A multigenic program mediating breast cancer metastasis to bone.
Metastasis suppressors alter the signal transduction of cancer cells
  • P. Steeg
  • Biology, Medicine
    Nature Reviews Cancer
  • 2003
Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified.
Evolutionary biology of cancer.