Genetic determinants of cancer metastasis

@article{Nguyen2007GeneticDO,
  title={Genetic determinants of cancer metastasis},
  author={D. Nguyen and J. Massagu{\'e}},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={341-352}
}
Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare tumour cells that overcame stringent physiological barriers as they separated from their original environment and developmental fate. This phenomenon brings into focus long-standing questions about the stage at which cancer cells acquire metastatic abilities, the relationship of metastatic cells to their tumour of origin, the basis for metastatic tissue tropism, the nature of metastasis predisposition… Expand

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