Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

  title={Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians},
  author={Allan Linneberg and Arturo Gonz{\'a}lez-Quintela and Carmen Vidal and Torben J{\o}rgensen and Mogens Fenger and Torben Hansen and Oluf Pedersen and L L N Husemoen},
  journal={Clinical \& Experimental Allergy},
Background Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol‐induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in… 

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  • A. TakaoT. Shimoda S. Kohno
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 1999

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