Genetic determinants of bone mass.

  title={Genetic determinants of bone mass.},
  author={Laura Aud{\'i} and Marta Garc{\'i}a-Ram{\'i}rez and Antonio Abad Carrascosa},
  journal={Hormone research},
  volume={51 3},
A genetic contribution to bone mass determination was first described in the early 70s. Elucidation of gene contribution to this has since been attempted through studies analyzing associations between bone mass acquisition and/or maintenance and polymorphic variations of several genes. The first to be described was the vitamin D receptor gene (VDR), initially claimed to contribute to almost 75% of the genetic variation in bone mineral density (BMD) in twin and general population studies. Not… CONTINUE READING