Genetic determinants for methotrexate response in juvenile idiopathic arthritis

@inproceedings{Pastore2015GeneticDF,
  title={Genetic determinants for methotrexate response in juvenile idiopathic arthritis},
  author={Serena Ifmach Pastore and Gabriele Stocco and Diego Favretto and Sara De Iudicibus and Andrea Taddio and Pio d’Adamo and Noelia Malus{\`a} and Riccardo Addobbati and Giuliana Decorti and Loredana Lepore and Alessandro Ventura},
  booktitle={Front. Pharmacol.},
  year={2015}
}
Juvenile idiopathic arthritis (JIAs) is the most common chronic rheumatic disease of childhood and is an important cause of disability. The folic acid analog methotrexate is the first choice disease-modifying anti-rheumatic drug in this disease, however, 35-45% of patients fail to respond. Molecular elements, such as variants in genes of pharmacological… CONTINUE READING